Vitamin D supplementation could possibly improve clinical outcomes of patients infected with COVID-19

See Vitamin D Supplementation Could Possibly Improve Clinical Outcomes of Patients Infected with Coronavirus-2019 (COVID-19). By Mark Alipio of Davao Doctors College; University of Southeastern Philippines.

Abstract

The rapid spread of COVID-19 in many areas of the world calls for preventive health measures. Although basic guidelines on infection control are suggested, treatment has remained the best choice to avert mortality. However, for the time being, there are no known vaccines for the disease. In this paper, a multinomial logistic regression was used to predict clinical outcomes of patients infected with COVID-19 based on 25-hydroxyvitamin D [25(OH)D] levels, the barometer for Vitamin D status. A retrospective multicentre study of 212 cases with laboratory-confirmed infection of SARS-CoV-2 was conducted. Data pertaining to clinical features and serum 25(OH)D levels were extracted from the medical records. For statistical analysis, Mann-Whitney U and χ² tests were used to compare differences in the clinical outcomes. Multinomial logistic regression was used to explore the association between serum 25(OH)D level and clinical outcomes of the cases. Frequency and percentage were used for categorical variables. Mean was used for continuous variables. A p-value below 0.01 was considered statistically significant. Of the 212 cases of COVID-19, majority had ordinary clinical outcome. Mean serum 25(OH)D level was 23.8 ng/ml. Serum 25(OH)D level was lowest in critical cases, but highest in mild cases. Serum 25(OH)D levels were statistically significant among clinical outcomes. Majority had insufficient Vitamin D status, most of them were not severe. Vitamin D status is significantly associated with clinical outcomes. A multinomial logistic regression analysis reported that for each standard deviation increase in serum 25(OH)D, the odds of having a mild clinical outcome rather than a severe outcome were approximately 7.94 times (OR=0.126, p<0 .001="" 19.61="" 25="" a="" an="" and="" approximately="" body="" clinical="" clinicians="" conclusion="" conduct="" controlled="" could="" covid-19.="" covid-2019="" critical="" d="" decrease="" either="" evaluate="" further="" having="" health="" improve="" in="" increase="" infected="" information="" interestingly="" large="" level="" mild="" mitigate="" odds="" of="" or="" outcome="" outcomes="" p="" patients.="" patients="" policy-makers.="" population="" possibly="" provides="" randomized="" rather="" recommendation.="" research="" results="" serum="" severe="" should="" studies="" study="" substantial="" suggest="" supplementation="" than="" that="" the="" this="" times="" to="" trials="" vitamin="" were="" while="" with="" worsen="" worst="">