Wednesday, June 10, 2020

Is the lockdown preventing an evolutionary process that moderate the effects of the virus?

See Covid and the Russian pandemic: From lethal pandemic to common cold: what we can learn from the events of 1889-90 by Matt Ridley. Excerpts:


"In addition to the new diseases of Sars, Mers and Covid-19, there are four other coronaviruses that infect people. They all cause common colds and are responsible for about one in five such sniffles, the rest being rhinoviruses and adenoviruses. As far as we can tell from their genes, two of these coronaviruses came from African bats (one of them bizarrely via alpacas or camels), and two from Asian rodents, one of them via cattle.

This last one, known as OC43, is the commonest of the cold coronaviruses. It comes around every winter and apparently sometimes reinfects people who have had it before. Unlike the other three, its origin is not lost in the mists of time but is known to be comparatively recent. Comparing its genetic sequence with that of its close bovine cousin, Dr Marc van Ranst at Leuven University in Belgium and his colleagues calculated in 2005 that they shared a common ancestor around the year 1890."

"If OC43 was the cause of the 1889-90 pandemic — far from proven, of course — and given that it is the cause of perhaps one in ten colds today, then it has evolved towards lower virulence. It is easy to see how this occurs with respiratory viruses, which are transmitted by people chatting and shaking hands. Mutations that affect the severity of the virus also tend to have an impact on whether people pass it on: if it sends you to bed feeling rotten, you will not give it to so many people. In the inevitable struggle for survival, the milder strains will gradually displace their nastier ones. This is why so many cold viruses affect us but so few kill us, except maybe when new to our species.

Perhaps, too, a degree of immune response in the population helps moderate the effects of the virus, even if not achieving full and permanent immunity. Some cross--immunity seems to exist today, whereby those who have had coronavirus colds do not catch, or do not suffer severely from, Covid-19.

Here is a disturbing thought: is lockdown preventing this evolutionary process, by confining the disease to settings where it can still thrive while being fatal, such as hospitals? Our fate is clear: without a vaccine or a cure, Covid-19 will fade, will be back, but will become less lethal till it is eventually indistinguishable from every other cold."

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