Quaaludes Might Be Back. The Iron Law of Prohibition Never Left.

This counts as progress in the war on drugs?

By Jeffrey A. Singer and Josh Bloom. Excerpts:

"In 1984, lawmakers passed legislation ordering methaqualone moved to Schedule I, the category reserved for drugs deemed to have "no currently accepted medical use and a high potential for abuse." Congress bypassed the Controlled Substances Act's normal scheduling procedures and ordered the Food and Drug Administration (FDA) to withdraw its approval." 

"Reports of renewed interest in methaqualone are now accompanied by another development: the emergence of methaqualone analogs, chemical cousins that may differ in potency and toxicity. The pattern resembles what we're seeing today with fentanyl analogs. A 2026 review reported that some methaqualone derivatives were roughly 100 times as potent as the original drug, while researchers still know little about their risk in human beings."

"In April 2026, the Center for Forensic Science Research and Education reported detecting 2-methoxyqualone, a structural analog of methaqualone, in illicit drug material collected in Pennsylvania and California.

Small changes to a drug's chemical structure can profoundly alter its pharmacological properties. In the case of 2-methoxyqualone, essentially nothing is known about its effects, potency, or toxicity in humans, as is the case with many illicit fentanyl analogs. From a synthetic chemistry standpoint, producing a virtually unlimited variety of methaqualone analogs is trivial, requiring relatively simple chemistry and readily available starting materials.

A 2026 scientific review identified five newer methaqualone analogs reportedly 100 times more potent than the original drug, although those potency estimates remain preliminary. Meanwhile, Australian drug-checking researchers identified a pill submitted as a Quaalude that actually contained methylmethaqualone. An earlier American clinical case report documented a patient who believed he had ingested methaqualone but had actually taken another analog, SL-164.

This emerging market offers another example of what drug policy analysts call the iron law of prohibition. As enforcement raises the risks and costs of supplying prohibited drugs, illicit suppliers have incentives to favor more potent substances that are easier to conceal and transport. Prohibition also encourages underground chemists to develop more potent chemical substitutes or to adulterate existing drugs with other substances to intensify their effects, exposing consumers to products of uncertain composition, potency, or toxicity.

The appearance of methaqualone analogs is consistent with that pattern. Although it is too early to establish that prohibition caused their development or that they are widely used, it's a pretty sure bet."